The Mitochondrion-Targeted Antioxidants in Kidney Disease

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Xinrui Li1, Liang Ma1, Ping Fu1

  • 1Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.

Current Medicinal Chemistry
|October 21, 2020
PubMed

Insights

Mitochondria generate reactive oxygen species (ROS) and dysfunction can harm organs like the kidney. Targeting mitochondria with antioxidants offers a new strategy for treating kidney diseases.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Nephrology

Background:

  • Mitochondria are key sources of cellular reactive oxygen species (ROS), and their dysfunction can lead to decreased adenosine triphosphate (ATP) levels and cell death.
  • Kidney diseases are often linked to mitochondrial dysfunction due to the kidney's high ATP consumption.

Purpose of the Study:

  • To review chemical and clinical characteristics of mitochondria-targeted antioxidants.
  • To focus on the application and future perspectives of these targeted antioxidants in kidney diseases.

Main Methods:

  • Literature review of chemical and clinical data on mitochondria-targeted antioxidants.
  • Analysis of various targeting strategies (e.g., triphenylphosphonium cation, peptides, nanocarriers).
  • Examination of different antioxidant payloads (e.g., nitroxides, quinones, vitamins).

Main Results:

  • Mitochondria-targeted antioxidants represent a promising therapeutic approach for kidney diseases.
  • Various chemical strategies and payloads are available for mitochondrial targeting.
  • Current research highlights the potential of these agents in preclinical and clinical settings.

Conclusions:

  • Mitochondrial targeting offers a novel therapeutic avenue for kidney diseases.
  • Further research is needed to fully elucidate the clinical efficacy and safety of these agents.
  • Targeted antioxidant delivery to mitochondria holds significant promise for managing renal pathologies.
Keywords:
Szeto-Schiller peptidesantioxidanthemigramicidin.kidney diseasemitochondria-targetedtriphenylphosphonium

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