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Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi'an stroke registry study of
Zhongzhong Liu1,2, Wenjuan Lin3, Qingli Lu1,2
1The First Affiliated Hospital of Northwest University, Xi'an, 710069, Shaanxi, China.
Insights
Outcomes for minor ischemic stroke (MIS) patients in Xi'an, China, are concerning, with high rates of disability. Age and pneumonia are key risk factors for poor 1-year outcomes in these patients.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Minor ischemic stroke (MIS) poses significant risks for recurrence, disability, and mortality.
- Understanding risk factors for adverse outcomes in MIS patients is crucial for effective management.
Purpose of the Study:
- To identify independent risk factors associated with 1-year adverse outcomes after minor ischemic stroke (MIS).
- To evaluate the prevalence of stroke recurrence, disability, and all-cause mortality in MIS patients in Xi'an, China.
Main Methods:
- A prospective cohort study involving 1121 MIS patients (NIHSS score ≤3) in Xi'an, China.
- 1-year follow-up to assess stroke recurrence, disability, and all-cause mortality.
- Multivariate logistic regression analysis to determine independent risk factors.
Main Results:
- Prevalence of stroke recurrence was 3.4%, disability 9.3%, and all-cause mortality 3.3% at 1 year.
- Independent risk factors for recurrence: age, smoking, pneumonia.
- Independent risk factors for mortality: age, pneumonia, alkaline phosphatase.
- Independent risk factors for disability: age, pneumonia, NIHSS score, leukocyte count.
Conclusions:
- 1-year outcomes for MIS patients in Xi'an are suboptimal, particularly regarding disability.
- Age and pneumonia are common independent risk factors impacting 1-year outcomes in MIS patients.
Background:
The prevalence of stroke recurrence, disability, and all-cause mortality of patients with minor ischemic stroke (MIS) remains problematic. The aim of the present study was to identify risk factors associated with adverse outcomes at 1 year after MIS in the Xi'an region of China.
Methods:
This prospective cohort study included MIS patients above 18 years old with National Institutes of Health Stroke Scale (NIHSS) score ≤ 3 who were treated in any of four hospitals in Xi'an region of China between January and December 2015. The 1-year prevalence of stroke recurrence, disability, and all-cause mortality were evaluated, respectively. Multivariate logistic regression analysis was performed to assess the association between the identified risk factors and clinical outcomes.
Results:
In this study, 131(10.5%, 131/1252) patients were lost to follow-up at 1 year. A total of 1121 patients were included for analysis, the prevalence of stroke recurrence, disability, and all-cause mortality at 1 year after MIS were 3.4% (38/1121), 9.3% (104/1121), and 3.3% (37/1121), respectively. Multivariate logistic regression analysis identified age, current smoking, and pneumonia as independent risk factors for stroke recurrence. Age, pneumonia, and alkaline phosphatase were independent risk factors for all-cause mortality. Independent risk factors for disability were age, pneumonia, NIHSS score on admission, and leukocyte count.
Conclusions:
The 1-year outcomes of MIS in Xi'an region of China were not optimistic, especially with a high prevalence of disability. The present study indicated that age and pneumonia were the common independent risk factors affecting the 1-year outcomes of MIS in Xi'an region of China.
