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Updated: Dec 5, 2025
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Sex Differences in Endovascular Treatment for Stroke: A Population-based Analysis
Charlotte Zerna1,2, Edwin Rogers3, Doreen M Rabi2,4
1Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Summary
Endovascular treatment (EVT) for acute ischemic stroke showed a trend toward less home-time benefit in women versus men. Age and treatment time confounded outcomes in women, suggesting personalized approaches are needed.
Area of Science:
- Neurology
- Vascular Medicine
- Public Health
Background:
- Acute ischemic stroke impacts men and women differently.
- Endovascular treatment (EVT) is a key intervention for large vessel occlusion stroke.
- Understanding sex-based outcome differences in EVT is crucial for personalized care.
Purpose of the Study:
- To evaluate sex differences in outcomes following endovascular treatment (EVT) for ischemic stroke.
- To assess the impact of EVT on 90-day home-time in men and women with large vessel occlusion stroke.
Main Methods:
- Population-based study in Alberta, Canada, analyzing 726 patients (576 EVT, 150 medical treatment).
- Data collected from administrative and linked databases over a 3-year period (April 2015-March 2018).
- Primary outcome: 90-day home-time, defined as days at premorbid living situation without increased care level.
Main Results:
- In adjusted analysis, EVT was associated with a 6.08-day increase in 90-day home-time for women (p=0.177) versus an 11.20-day increase for men (p=0.018).
- A nonsignificant nominal reduction in 90-day home-time gain was observed for women compared to men.
- Age and onset-to-treatment time were identified as confounders for the association between EVT and 90-day home-time in women.
Conclusions:
- This study found a trend towards a smaller home-time benefit from EVT in women compared to men for large vessel occlusion stroke.
- Confounding factors partially explained the observed differences in women.
- Further research is needed to elucidate sex-specific factors influencing EVT outcomes.
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