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Acromegaly.

¹Middlesex Hospital, London.

Clinical Endocrinology

|April 1, 1987

Summary

This study describes 256 acromegaly/gigantism cases, highlighting diagnostic delays and common symptoms like headaches and appearance changes. Successful treatment can normalize growth hormone levels and improve associated conditions such as hypertension and diabetes.

Area of Science:

Endocrinology
Oncology
Cardiology

Background:

Acromegaly and gigantism are rare conditions caused by excess growth hormone (GH).
Delayed diagnosis is common due to the insidious onset of symptoms.
This series reviews a significant number of cases over two decades.

Purpose of the Study:

To describe the clinical features and outcomes of 256 acromegaly/gigantism patients.
To analyze diagnostic delays and presenting symptoms.
To evaluate the impact of treatment on various associated comorbidities and mortality.

Main Methods:

Retrospective analysis of 256 patient cases from 1963-1983.
Utilized the Hardy system for radiological grading of pituitary tumors.
Documented symptoms, clinical features, comorbidities, and treatment outcomes.

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Main Results:

Diagnosis was often delayed, with common presenting symptoms including headache, altered appearance, carpal tunnel syndrome, amenorrhea, and diabetes.
Hypertension incidence was increased but responsive to treatment; coronary artery disease was not.
Diabetes mellitus resolved in most cases post-treatment; increased mortality was observed, particularly in women and younger men.

Conclusions:

Acromegaly presents with diverse symptoms, often leading to diagnostic delays.
Treatment can effectively manage comorbidities like hypertension and diabetes.
Increased mortality rates underscore the systemic impact of untreated acromegaly.