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Related Experiment Videos

Acromegaly.

J D Nabarro1

  • 1Middlesex Hospital, London.

Clinical Endocrinology
|April 1, 1987
PubMed
Summary
This summary is machine-generated.

This study describes 256 acromegaly/gigantism cases, highlighting diagnostic delays and common symptoms like headaches and appearance changes. Successful treatment can normalize growth hormone levels and improve associated conditions such as hypertension and diabetes.

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Area of Science:

  • Endocrinology
  • Oncology
  • Cardiology

Background:

  • Acromegaly and gigantism are rare conditions caused by excess growth hormone (GH).
  • Delayed diagnosis is common due to the insidious onset of symptoms.
  • This series reviews a significant number of cases over two decades.

Purpose of the Study:

  • To describe the clinical features and outcomes of 256 acromegaly/gigantism patients.
  • To analyze diagnostic delays and presenting symptoms.
  • To evaluate the impact of treatment on various associated comorbidities and mortality.

Main Methods:

  • Retrospective analysis of 256 patient cases from 1963-1983.
  • Utilized the Hardy system for radiological grading of pituitary tumors.
  • Documented symptoms, clinical features, comorbidities, and treatment outcomes.

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Main Results:

  • Diagnosis was often delayed, with common presenting symptoms including headache, altered appearance, carpal tunnel syndrome, amenorrhea, and diabetes.
  • Hypertension incidence was increased but responsive to treatment; coronary artery disease was not.
  • Diabetes mellitus resolved in most cases post-treatment; increased mortality was observed, particularly in women and younger men.

Conclusions:

  • Acromegaly presents with diverse symptoms, often leading to diagnostic delays.
  • Treatment can effectively manage comorbidities like hypertension and diabetes.
  • Increased mortality rates underscore the systemic impact of untreated acromegaly.