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[Research progress of coagulation dysfunction in coronavirus disease 2019]
Shengjian Zhong1,2, Fengfu Wu1,2, Na Peng2,3
1Department of Critical Care Medicine, the 923th Hospital of Joint Logistics Support Forces of PLA, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|October 21, 2020
Summary
Coronavirus disease 2019 (COVID-19) significantly impacts multiple organs, with severe cases often showing coagulation dysfunction. Elevated D-dimer levels are a key indicator, affecting patient prognosis and mortality.
Area of Science:
- Infectious Diseases
- Hematology
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic with multi-organ effects.
- Coagulation dysfunction is a significant complication, particularly in severe and critical COVID-19 cases.
- Elevated D-dimer levels are a primary characteristic of COVID-19-associated coagulopathy.
Purpose of the Study:
- To review the clinical manifestations of COVID-19.
- To identify risk factors associated with coagulation dysfunction in COVID-19 patients.
- To explore the mechanisms and evaluation methods for COVID-19-related coagulation disorders.
Main Methods:
- Literature review of existing studies on COVID-19 and coagulation.
- Analysis of clinical data regarding manifestations and risk factors.
- Synthesis of information on pathophysiological mechanisms.
- Review of diagnostic and evaluation techniques for coagulation function.
Main Results:
- COVID-19 presents with diverse clinical manifestations.
- Several risk factors contribute to coagulation dysfunction in severe COVID-19.
- Coagulation abnormalities, marked by high D-dimer, are prevalent.
- Coagulopathy directly impacts patient outcomes and mortality.
Conclusions:
- Coagulation dysfunction is a critical factor in COVID-19 prognosis.
- Understanding these mechanisms is vital for managing severe cases.
- Further research into coagulation management is warranted.
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