Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ovarian prorenin.

J E Sealey1, N Glorioso, J Itskovitz

  • 1Cardiovascular Center, New York Hospital-Cornell University Medical College, New York 10021.

Clinical and Experimental Hypertension. Part A, Theory and Practice
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MEASUREMENT OF ALDOSTERONE SECRETION AND EXCRETION RATES BY A DOUBLE ISOTOPE DILUTION TECHNIC.

A listing of research in the cardiovascular field·2014
Same author

Conceptual basis and methodology of the SOPHIA study.

Pharmacogenomics·2007
Same author

Pharmacogenomics of essential hypertension: are we going the right way?

Cardiovascular & hematological agents in medicinal chemistry·2006
Same author

A free-ranging roundtable discussion on hypertension.

Journal of human hypertension·2005
Same author

Genetic polymorphisms of the beta-adrenergic system: association with essential hypertension and response to beta-blockade.

The pharmacogenomics journal·2004
Same author

Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.

Journal of hypertension·2001
Same journal

Cardiovascular responses to centrally applied sodium chloride solution.

Clinical and experimental hypertension. Part A, Theory and practice·1992
Same journal

Selected abstracts from the 14th annual meeting of the Japanese Societies of Hypertension.

Clinical and experimental hypertension. Part A, Theory and practice·1992
Same journal

Insulin attenuates vasoconstriction by noradrenaline, serotonin and potassium chloride in rat mesenteric arterioles.

Clinical and experimental hypertension. Part A, Theory and practice·1992
Same journal

Renal nerve-mediated proximal tubule solute reabsorption contributes to hypertension in spontaneously hypertensive rats.

Clinical and experimental hypertension. Part A, Theory and practice·1992
Same journal

Chlorthalidone reduces vascular hyperresponsiveness in DOCA-salt hypertensive rats.

Clinical and experimental hypertension. Part A, Theory and practice·1992
Same journal

Electrophysiological responses of angiotensin peptides on the rat isolated nodose ganglion.

Clinical and experimental hypertension. Part A, Theory and practice·1992
See all related articles

The ovaries produce and release prorenin, particularly during ovulation and early pregnancy, in response to gonadotropic hormones. This suggests a role for ovarian prorenin in reproductive function.

Area of Science:

  • Reproductive Endocrinology
  • Renal Physiology
  • Hormone Biology

Background:

  • The renin-angiotensin system (RAS) is crucial for blood pressure regulation.
  • Prorenin, an inactive precursor of renin, is primarily found in plasma.
  • The ovary's role in prorenin production has been increasingly recognized.

Purpose of the Study:

  • To review evidence for ovarian synthesis and secretion of prorenin.
  • To investigate the regulation of ovarian prorenin by gonadotropic hormones.
  • To explore the potential role of ovarian prorenin in human reproduction.

Main Methods:

  • Review of existing literature on ovarian prorenin.
  • Analysis of plasma prorenin levels during the menstrual cycle and pregnancy.

Related Experiment Videos

  • Comparison of prorenin levels in hyperstimulated cycles and with donor eggs.

    • Main Results:

    • Ovaries contain high concentrations of prorenin in follicular fluid.
    • Plasma prorenin, not active renin, increases at mid-cycle ovulation.
    • Ovarian hyperstimulation and early pregnancy significantly elevate plasma prorenin.
    • Ovarian failure negates the pregnancy-related prorenin increase.

    Conclusions:

    • The ovaries synthesize and secrete prorenin, stimulated by gonadotropins.
    • Ovarian prorenin may play a role in reproductive function.
    • A potential prorenin receptor could activate local RAS within the ovary.