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Related Concept Videos

Burn Injuries01:22

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Related Experiment Video

Updated: Dec 5, 2025

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
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Cell salvage in burn excisional surgery.

Rolf K Gigengack1, Veerle Verhees2, Ankie W M M Koopman-van Gemert3

  • 1Departments of Trauma and Burn Surgery, Maasstad Ziekenhuis, Rotterdam, The Netherlands; Department of Anesthesiology, Amsterdam UMC, Location De Boelelaan, Amsterdam, The Netherlands.

Burns : Journal of the International Society for Burn Injuries
|October 21, 2020
PubMed
Summary

Cell salvage is feasible for recovering red blood cells during burn surgery, concentrating them effectively. However, all salvaged erythrocyte concentrates showed bacterial contamination, requiring further investigation.

Keywords:
BloodBurn excisional surgeryCell salvageMicrobial contaminationTransfusion

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Area of Science:

  • Surgery
  • Anesthesiology
  • Transfusion Medicine

Background:

  • Achieving hemostasis during burn surgery is challenging, often leading to significant blood loss and the need for allogeneic blood transfusions.
  • Existing bleeding control measures are limited, highlighting the need for alternative strategies to reduce transfusion requirements in burn patients.

Purpose of the Study:

  • To investigate the feasibility of implementing cell salvage techniques during burn surgery.
  • To evaluate the quality and safety of salvaged erythrocytes for potential reinfusion.

Main Methods:

  • A prospective, observational study involving 16 patients undergoing major burn surgery.
  • Blood recovery via washing gauze pads with heparinized saline, followed by processing with a Cell Saver.
  • Analysis of erythrocyte concentrate quality (hemoglobin, hematocrit, potassium, free hemoglobin) and microbial contamination.

Main Results:

  • The cell salvage process recovered 29% ± 11% of the lost red blood cell mass.
  • Salvaged erythrocyte concentrates demonstrated a concentration effect, with increased hemoglobin and hematocrit levels.
  • While potassium levels were reduced and free hemoglobin was low, all concentrates showed bacterial growth despite sterile handling.

Conclusions:

  • Cell salvage is a possible method for recovering erythrocytes during burn excisional surgery.
  • Bacterial contamination was consistently observed in salvaged erythrocyte concentrates, irrespective of sterile handling protocols.
  • The clinical implications of bacterial contamination in cell-salvaged blood for burn patients require further research.