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PAT in the ER for Transmembrane Protein Folding

Prabuddha S Pathinayake1, Alan C-Y Hsu1, Peter A B Wark2

  • 1Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.

Trends in Biochemical Sciences
|October 21, 2020
PubMed
Summary

A new chaperone complex helps integral membrane proteins (IMPs) fold correctly within the cell membrane. This discovery reveals key mechanisms for assembling IMPs with multiple transmembrane domains (TMDs) in the endoplasmic reticulum.

Keywords:
PAT complexchaperoneendoplasmic reticulummembrane proteins

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