Related Experiment Video

Updated: Dec 5, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

The relationship between axial length, age and intraocular pressure in children with primary congenital glaucoma

Ibrahim Al-Obaida1, Adi Mohammed Al Owaifeer1,2, Khabir Ahmad3

  • 1Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Scientific Reports
|October 21, 2020
PubMed

Insights

Axial length (AxL) growth in children with primary congenital glaucoma (PCG) is primarily influenced by age. This study developed a model to predict expected AxL increase, aiding in identifying progressive glaucoma cases.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Glaucoma Research

Background:

  • Axial length (AxL) is crucial for monitoring pediatric glaucoma progression.
  • Differentiating AxL changes from age versus elevated intraocular pressure (IOP) is challenging.
  • Existing normograms lack sufficient data from children with glaucoma.

Purpose of the Study:

  • To evaluate the relationship between AxL, age, and IOP in children with primary congenital glaucoma (PCG).
  • To develop a predictive model for expected AxL increase with age in PCG patients.
  • To improve the clinical identification of progressive glaucoma in children.

Main Methods:

  • Retrospective analysis of 208 children (397 eyes) with PCG from June 2014 to July 2018.
  • Inclusion of axial length (AxL) and intraocular pressure (IOP) measurements.
  • Application of LOWESS fit and mixed-effects models to analyze data.

Main Results:

  • Age was the most significant factor influencing AxL growth (p < 0.001).
  • AxL growth association was influenced by IOP-sex interaction, number of antiglaucoma medications (AGM), and glaucoma surgery.
  • A model was developed to predict expected AxL values in children with PCG.

Conclusions:

  • A novel model accurately predicts axial length (AxL) changes in children with primary congenital glaucoma (PCG).
  • Age is the primary driver of AxL growth, modulated by IOP, sex, medications, and surgery.
  • This model aids in distinguishing glaucoma-related AxL changes from normal aging, improving diagnostic accuracy.

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.7K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
856
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
981