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Multifocal Meningioma Recurrence Detected on Ga68-DOTANOC Scan
1Department of Nuclear Medicine, Sir Ganga Ram Hospital, New Delhi, India.
Abstract:
Meningiomas arise from meningothelial cells of the arachnoid membranes. They are classified into three grades according to the WHO criteria, Grade I (Benign), Grade II (atypical), and Grade III (anaplastic). Radiological and structural imaging computed tomography (CT) and magnetic resonance imaging are done routinely for defining the location, extent, and follow-up. However, these imaging techniques have their limitations. Since meningiomas have overexpression of somatostatin receptor 2, DOTANOC positron-emission tomography (PET)/CT scan is suggested for their delineation and distinguish postradiotherapy necrosis from recurrence. Here, we present a case where DOTANOC PET/CT scan helped in confirming recurrence postsurgery and radiotherapy.
Insights
DOTANOC positron-emission tomography (PET)/CT scans can confirm meningioma recurrence after surgery and radiotherapy. This advanced imaging is useful when traditional methods like CT and MRI have limitations in diagnosis.
Area of Science:
- Neuro-oncology
- Medical imaging
- Nuclear medicine
Background:
- Meningiomas are tumors originating from arachnoid membrane meningothelial cells.
- WHO grading classifies meningiomas into Grade I (Benign), Grade II (Atypical), and Grade III (Anaplastic).
- Conventional imaging (CT, MRI) has limitations in defining tumor extent and recurrence.
Purpose of the Study:
- To present a case demonstrating the utility of DOTANOC PET/CT in diagnosing meningioma recurrence.
- To highlight the role of DOTANOC PET/CT in differentiating post-treatment changes from tumor regrowth.
Main Methods:
- Utilized DOTANOC positron-emission tomography (PET)/CT scan for diagnostic imaging.
- The scan leverages the overexpression of somatostatin receptor 2 in meningiomas.
Main Results:
- DOTANOC PET/CT successfully confirmed meningioma recurrence in the presented case.
- This imaging modality aided in distinguishing recurrence from post-radiotherapy necrosis.
Conclusions:
- DOTANOC PET/CT is a valuable tool for diagnosing meningioma recurrence post-surgery and radiotherapy.
- Its ability to delineate tumor activity offers advantages over conventional imaging techniques in specific clinical scenarios.
