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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers

Dan Wang1, Mingyue Li2, Jing Li3

  • 1State Key Laboratory of Genetic Engineering, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Science, Fudan University, Shanghai 200433, China.

Disease Markers
|October 21, 2020
PubMed

Insights

Androgen-responsive long noncoding RNAs (lncRNAs) are newly identified as key players in hormone-related cancers. These novel lncRNAs offer potential as molecular biomarkers for cancer progression and outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • The androgen receptor (AR) signaling pathway is crucial in hormone-related cancers.
  • The role of androgen-responsive long noncoding RNAs (lncRNAs) in these cancers is largely unknown.

Purpose of the Study:

  • To identify and characterize novel androgen-responsive lncRNAs.
  • To elucidate the regulatory networks and functions of these lncRNAs in hormone-related cancers.
  • To assess their potential as prognostic biomarkers.

Main Methods:

  • Microarray analysis to identify androgen-responsive lncRNAs.
  • ChIP-seq data to construct transcriptional regulatory networks.
  • Bioinformatics analysis to build lncRNA-miRNA-mRNA networks.
  • TCGA data for coexpression and protein-protein interaction (PPI) network analyses.
  • Gene Ontology (GO) and KEGG pathway analyses.

Main Results:

  • Identified 469 novel androgen-responsive lncRNAs.
  • Constructed transcriptional networks involving over 30 transcription factors.
  • Revealed lncRNA-miRNA-mRNA regulatory interactions.
  • Identified key biological processes including signal transduction, transcription, development, cell adhesion, immune response, cell differentiation, and MAPK signaling.
  • Highlighted prognostic significance of HPN-AS1, TPTEP1, and LINC00623.

Conclusions:

  • Androgen-responsive lncRNAs are integral to hormone-related cancer progression.
  • These lncRNAs regulate critical cellular pathways.
  • Novel lncRNAs like HPN-AS1, TPTEP1, and LINC00623 show promise as cancer biomarkers.

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