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Liver injury in COVID-19: A minireview

Jian-Nan Zhao1, Ying Fan2, Shuo-Dong Wu1

  • 1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

World Journal of Clinical Cases
|October 21, 2020
PubMed

Insights

Novel coronavirus disease 2019 (COVID-19) can cause liver injury. This review highlights the importance of monitoring and treating liver damage in COVID-19 patients, including those who have undergone liver transplantation.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • An outbreak of novel coronavirus disease 2019 (COVID-19) emerged in late 2019.
  • Liver injury is a recognized complication in COVID-19 patients, with varying severity.
  • Factors contributing to liver injury include systemic inflammation, immune response, and direct viral effects.

Purpose of the Study:

  • To review the existing literature on liver injury associated with COVID-19.
  • To emphasize the clinical significance of monitoring and managing liver dysfunction in COVID-19.
  • To address concerns regarding COVID-19 infection in liver transplant recipients.

Main Methods:

  • Literature review of studies on COVID-19 and liver injury.
  • Analysis of reported cases and contributing factors to liver damage.
  • Synthesis of information regarding clinical monitoring and treatment strategies.

Main Results:

  • COVID-19 can manifest with varying degrees of liver injury.
  • Multiple mechanisms, including inflammation and direct viral impact, contribute to liver damage.
  • Most cases show mild, transient liver dysfunction, but monitoring is crucial, especially for vulnerable populations like liver transplant recipients.

Conclusions:

  • Liver injury is a significant clinical manifestation of COVID-19 that requires attention.
  • Close monitoring and appropriate management of liver function are essential for COVID-19 patients.
  • Further research is needed to fully understand and manage COVID-19-related liver injury, particularly in immunocompromised individuals.

Keywords:
COVID-19Hepatoprotective drugsLiver injuryNovel coronavirusPandemicSARS-CoV-2

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