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Related Experiment Video

Updated: Dec 5, 2025

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
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Isolated night cough in children: how does it differ from wheeze?

Maja Jurca1, Myrofora Goutaki1,2, Philipp Latzin2

  • 1Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

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|October 21, 2020
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Summary

Recurrent cough in children without wheezing is not a reliable indicator of future asthma. This study found distinct risk factors for cough and wheeze, with little evidence supporting cough variant asthma.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Recurrent cough without wheeze in children is sometimes considered cough variant asthma.
  • This condition is hypothesized to share risk factors with asthma and increase future wheeze risk.

Purpose of the Study:

  • To compare risk factors for isolated night cough and wheeze in children.
  • To compare the prognosis of children with isolated night cough, wheeze, and asymptomatic children.

Main Methods:

  • Longitudinal study of the Leicester Respiratory Cohort.
  • Included children aged 1, 4, 6, and 9 years.
  • Analyzed prevalence, risk factors, and prognosis of cough and wheeze.

Main Results:

  • Isolated night cough prevalence was 10% at age 1 and 18% in older children; wheeze prevalence decreased from 35% to 13%.
  • Risk factors differed: daycare, reflux, and bronchitis history linked to cough; male sex and asthma history linked to wheeze.
  • Children with preschool cough often continued coughing but had similar future wheeze risk as asymptomatic children.

Conclusions:

  • Shared risk factors for cough and wheeze were limited.
  • Little evidence supports the hypothesis that recurrent cough without wheeze indicates a variant form of asthma.
  • Wheeze showed stronger tracking throughout childhood compared to cough.