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Related Experiment Video

Updated: Dec 5, 2025

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

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Migrainous Infarction and Cortical Spreading Depression.

Waleed Iftikhar1, Fatima Fayyaz Cheema1, Sneha Khanal2

  • 1CMH Lahore Medical College and Institute of Dentistry (NUMS), Lahore, Pakistan.

Discoveries (Craiova, Romania)
|October 21, 2020
PubMed
Summary

Migraine with aura can rarely lead to migrainous infarction due to cortical spreading depression. This process involves vasoconstriction and hypercoagulability, increasing stroke risk and highlighting the link between migraine and cerebrovascular events.

Keywords:
Migrainous infarctioncortical spreading depressionmigrainemigraine with aura

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Area of Science:

  • Neurology
  • Neuroscience
  • Vascular Biology

Background:

  • Migraine is a common neurological disorder.
  • Migrainous infarction, a rare complication of migraine with aura, shares physiological links with stroke.
  • Cortical spreading depression (CSD) is implicated in migraine aura symptoms and can precipitate migrainous infarction.

Purpose of the Study:

  • To elucidate the relationship between migraine-induced stroke and cortical spreading depression.
  • To explore the hemodynamic and genetic factors connecting migraine and stroke.
  • To highlight the clinical significance of investigating cortical depression.

Main Methods:

  • Review of physiological processes linking migraine and stroke.
  • Analysis of the role of cortical spreading depression in cerebrovascular events.
  • Examination of genetic disorders associated with both migraine and stroke.

Main Results:

  • Cortical spreading depression can cause extreme vasoconstriction and endothelial damage.
  • Endothelial damage contributes to hypercoagulability, elevating stroke risk.
  • Understanding genetic disorders offers insights into migrainous infarction mechanisms.

Conclusions:

  • Cortical spreading depression is a key mechanism linking migraine aura to infarction.
  • Vascular dysfunction in migraine presents potential therapeutic targets.
  • Further research into hemodynamic and genetic factors is crucial for understanding migraine-related stroke.