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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Liver Function Enzymes are Potential Predictive Markers for Kidney Allograft Dysfunction.

Alakesh Bera1, Eric Russ1, Rahul M Jindal2

  • 1Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.

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|October 21, 2020
PubMed
Summary
This summary is machine-generated.

Alkaline phosphatase (ALP) shows promise as a biomarker for kidney transplant health, potentially reducing the need for invasive biopsies. Elevated liver enzymes like AST and ALT may indicate graft rejection.

Keywords:
Kidney allograft rejectionSerum alkaline phosphatasechronic kidney diseasenon-invasive biomarker

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Area of Science:

  • Nephrology
  • Transplant Immunology
  • Biomarker Discovery

Background:

  • Kidney allograft biopsy is the standard for assessing dysfunction.
  • Developing non-invasive biomarkers is crucial for patient care.

Purpose of the Study:

  • To identify serum biomarkers that can predict kidney allograft dysfunction and obviate the need for biopsy.
  • To evaluate alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST) as potential biomarkers.

Main Methods:

  • Serum samples from four groups were analyzed: unstable kidney allografts, stable kidney allografts, chronic kidney disease (CKD) patients, and healthy individuals (n=25 each).
  • Activity and levels of ALP, ALT, and AST were measured.

Main Results:

  • ALP correlated with allograft biopsy findings, liver function, and clinical outcomes, suggesting a role in graft survival.
  • Higher AST and ALT levels were observed in patients with graft rejection compared to stable transplants.
  • ALP showed low correlations with age, BMI, creatinine, and eGFR, indicating it may be an independent biomarker.

Conclusions:

  • Alkaline phosphatase (ALP) is a potential biomarker for predicting kidney allograft function and rejection.
  • Liver function is important for successful kidney transplantation.