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Updated: Dec 5, 2025
07:15
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
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Associations Between Genetically Predicted Protein Levels and COVID-19 Severity
Jingjing Zhu1, Chong Wu2, Lang Wu1
1Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
The Journal of Infectious Diseases
|October 21, 2020
Summary
Identifying potential drug targets for severe COVID-19 is crucial. This study found 18 proteins genetically linked to COVID-19 severity, offering new avenues for drug repurposing and therapeutic strategies.
Area of Science:
- Genetics
- Immunology
- Pharmacology
Background:
- Identifying causal targets for SARS-CoV-2 is essential for drug repurposing.
- Understanding host genetic factors influencing COVID-19 severity is critical.
Purpose of the Study:
- To investigate associations between genetically predicted protein levels and COVID-19 severity.
- To identify potential protein targets for therapeutic interventions against severe COVID-19.
Main Methods:
- Utilized data from the COVID-19 Host Genetics Initiative.
- Performed a large-scale genetic association study comparing hospitalized COVID-19 patients (6,492) and controls (1,012,809).
- Analyzed genetically predicted protein levels for association with COVID-19 severity using stringent statistical thresholds (FDR <0.05, Bonferroni correction).
Main Results:
- Identified 18 proteins with genetically predicted levels associated with COVID-19 severity.
- Twelve of these proteins remained significant after Bonferroni correction.
- Six proteins showed positive associations, while 12 demonstrated inverse associations with disease severity.
Conclusions:
- Discovered 18 candidate proteins potentially influencing COVID-19 severity.
- These findings provide a foundation for exploring novel therapeutic targets and drug repurposing strategies for severe COVID-19.
- The identified proteins represent promising avenues for future research into COVID-19 pathogenesis and treatment.
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