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Major gaps in human evidence for structure and function of the vasa vasora limit our understanding of the link with

Bichen Sophie Zhao1, Hanane Belhoul-Fakir2,3, Shirley Jansen1,4,5,6

  • 1Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Journal of Anatomy
|October 21, 2020
PubMed

Insights

The vasa vasora (VV) are small vessels supplying arteries. While linked to atherosclerosis progression, their role in plaque initiation requires further investigation.

Area of Science:

  • Cardiovascular Biology
  • Vascular Anatomy
  • Pathogenesis of Atherosclerosis

Background:

  • Atherosclerosis is a leading cause of death globally, with risk factor modification improving outcomes but not offering a cure.
  • The vasa vasora (VV), small vessels nourishing the arterial wall, are implicated in atherosclerotic plaque progression and thrombosis.
  • The specific role of VV in the initiation of atherosclerotic plaque remains poorly understood.

Purpose of the Study:

  • To review the current evidence on the anatomy and function of the vasa vasora (VV).
  • To explore the relationship between VV and the initiation of atherosclerosis.
  • To identify inconsistencies and limitations in the existing research on VV and atherosclerosis.

Main Methods:

  • Literature review of studies investigating vasa vasora anatomy, function, and their role in vascular disease.
  • Synthesis of evidence linking VV to atherosclerotic plaque progression and thrombosis.
  • Critical analysis of research pertaining to VV's involvement in plaque initiation.

Main Results:

  • Convincing evidence supports the association of VV with atherosclerotic plaque progression and thrombosis.
  • The contribution of VV to the initial stages of atherosclerotic plaque formation is less clear and requires more research.
  • Existing studies highlight inconsistencies and limitations in understanding the precise role of VV in atherosclerosis.

Conclusions:

  • Vasa vasora (VV) play a significant role in established atherosclerotic plaques and thrombosis.
  • Further research is needed to elucidate the exact mechanisms by which VV contribute to the initiation of atherosclerosis.
  • Addressing the limitations and inconsistencies in current evidence is crucial for a comprehensive understanding of VV's role in cardiovascular disease.

Keywords:
atherosclerosisvasa vasora

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