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Process hybridization schemes for multiscale engineered tissue biofabrication.

Parth Chansoria1,2, Karl Schuchard1,2, Rohan A Shirwaiker1,2,3

  • 1Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, North Carolina, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|October 21, 2020
PubMed
Summary
This summary is machine-generated.

Hybrid biofabrication strategies combining multiple techniques are essential for recreating complex tissue structures. This approach overcomes limitations of single methods, enabling biomimetic tissue engineering across nano to macro scales.

Keywords:
biofabricationbiomimeticshybrid processestissue engineering and regenerative medicine

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology in Biology

Background:

  • Recreating multiscale cellular and extracellular matrix properties is key for biomimetic tissue substitutes.
  • Existing biofabrication methods, though diverse, often have limitations when used individually.
  • Focus on single processes restricts the creation of tissues with features spanning nano to macro scales.

Purpose of the Study:

  • To review hybrid biofabrication strategies for biomimetic tissue engineering.
  • To guide the selection of synergistic processes for multiscale tissue reconstruction.
  • To discuss opportunities and future outlook in scale-up biofabrication.

Main Methods:

  • Literature review of hybrid biofabrication strategies.
  • Classification of biofabrication processes (fiber formation, additive manufacturing, surface modification, remote fields, etc.).
  • Analysis of synergistic combinations of multiple biofabrication techniques.

Main Results:

  • Hybrid strategies unite multiple processes to leverage complementary strengths and overcome individual limitations.
  • Combining techniques allows for the recapitulation of complex multiscale structure-function properties.
  • This approach is crucial for engineering relevant tissue features from the nanoscale to the macroscale.

Conclusions:

  • Hybrid biofabrication is critical for achieving multiscale biomimicry in tissue engineering.
  • Synergistic integration of processes enables the creation of advanced tissue substitutes.
  • Further development in hybridization and scale-up is essential for future applications.