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Acne fulminans.

Federica Dall'oglio1, Davide F Puglisi1, Maria R Nasca1

  • 1Dermatology Clinic, University of Catania, Catania, Italy.

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|October 21, 2020
PubMed
Summary
This summary is machine-generated.

Acne fulminans is a severe inflammatory skin condition with painful pustules and ulcers, sometimes with systemic symptoms. Treatment involves corticosteroids and retinoids, with other options for difficult cases.

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Area of Science:

  • Dermatology
  • Inflammatory Diseases
  • Autoimmune Disorders

Background:

  • Acne fulminans (AF) is a rare, severe inflammatory skin condition.
  • Characterized by sudden onset of painful, hemorrhagic pustules and ulcerations.
  • May present with systemic symptoms like fever and polyarthritis, often in teenage males with prior acne.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and treatment of Acne Fulminans.
  • To discuss the classification and potential pathogenetic factors of AF.
  • To outline current and alternative therapeutic strategies for AF.

Main Methods:

  • Literature review of Acne Fulminans.
  • Analysis of clinical presentation and diagnostic criteria.
  • Summary of treatment modalities, including first-line and alternative therapies.

Main Results:

  • AF diagnosis relies on clinical history and examination; specific lab abnormalities are uncommon.
  • Four clinical variants proposed: AF with/without systemic symptoms (AF-SS/AF-WOSS) and isotretinoin-induced variants (IIAF-SS/IIAF-WOSS).
  • Systemic corticosteroids and retinoids are primary treatments; other agents are used for refractory cases.

Conclusions:

  • Acne fulminans requires tailored treatment based on severity and systemic involvement.
  • Early diagnosis and appropriate management are crucial for patient outcomes.
  • Further research into pathogenesis may reveal novel therapeutic targets.