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Updated: Dec 5, 2025

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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First-line immunotherapy versus targeted therapy in patients with BRAF-mutant advanced melanoma: a real-world

Anna C Pavlick1, Ruizhi Zhao2, Cho-Han Lee2

  • 1Weill Cornell Medical Center, New York, NY 10021, USA.

Future Oncology (London, England)
|October 21, 2020
PubMed

Aim: To compare effectiveness of nivolumab + ipilimumab (NIVO + IPI) versus BRAF + MEK inhibitors (BRAFi + MEKi) in patients with BRAF-mutant advanced melanoma in the real-world setting. Materials & methods: This study used the Flatiron Health electronic medical record database. Results: After adjusting for differences in baseline characteristics, NIVO + IPI was associated with a 32% reduction in risk of death versus BRAFi + MEKi. At a mean follow-up of 15-16 months, 64% of NIVO + IPI patients and 43% of BRAFi + MEKi patients were alive; subsequent therapy was administered to 33 and 41% of patients, respectively. After first-line NIVO + IPI, 20% of patients died before subsequent therapy, whereas 32% died after first-line BRAFi + MEKi. Conclusion: In this real-world study, patients treated with first-line NIVO + IPI showed significant survival benefit versus those receiving first-line BRAFi + MEKi.

Keywords:
BRAF and MEK inhibitorsadvanced melanomanivolumab plus ipilimumabreal-world study

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