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Related Concept Videos

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
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Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models
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FlowTriever System for mechanical thromboembolectomy.

Hamid R Mojibian1, Eric Chow1, Jeffery Pollak1

  • 1Department of Radiology & Biomedical Imaging, Section of Vascular & Interventional Radiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Future Cardiology
|October 21, 2020
PubMed
Summary

Thrombolytic therapy for pulmonary embolism carries bleeding risks. The Inari FlowTriever System offers mechanical thrombectomy as an alternative, potentially avoiding thrombolytics and their associated bleeding complications.

Keywords:
FlowTrievercatheter directed therapypulmonary embolismresidual pulmonary vascular obstructionthromboembolectomythrombolysisvenous thromboembolism

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Area of Science:

  • Cardiology
  • Interventional Radiology
  • Medical Devices

Background:

  • Thrombolytic therapy is a standard treatment for massive and submassive pulmonary embolism.
  • Bleeding complications can limit the use of thrombolytics.
  • Percutaneous mechanical thrombectomy presents an alternative to thrombolysis, especially for patients with contraindications.

Purpose of the Study:

  • To review the Inari FlowTriever System, a novel large-bore aspiration thrombectomy device.
  • To discuss its clinical applications and current evidence for pulmonary embolism treatment.
  • To explore future research avenues for this technology.

Main Methods:

  • Review of existing literature on the Inari FlowTriever System.
  • Analysis of clinical data and case studies related to its use in pulmonary embolism.
  • Discussion of the device's mechanism of action and technical aspects.

Main Results:

  • The Inari FlowTriever System is the first FDA-cleared device for pulmonary embolism thrombectomy.
  • It offers a mechanical approach to remove pulmonary artery clots.
  • Early data suggests potential efficacy and safety in select patient populations.

Conclusions:

  • The Inari FlowTriever System provides a valuable alternative to thrombolysis for pulmonary embolism.
  • It may reduce bleeding risks associated with lytic therapy.
  • Further research is warranted to define its optimal role in clinical practice.