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Updated: Dec 5, 2025

Author Spotlight: Coproparasitoscopic Examination of Dog Stools for Control and Prevention of Zoonotic Parasite Diseases
Published on: December 15, 2023
Subtype distribution of zoonotic pathogen Cryptosporidium felis in humans and animals in several countries
Wen Jiang1,2, Dawn M Roellig2, Marianne Lebbad3
1School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Abstract:
Cryptosporidium felis is the major etiologic agent of cryptosporidiosis in felines and has been reported in numerous human cryptosporidiosis cases. Sequence analysis of the 60-kDa glycoprotein (gp60) gene has been developed for subtyping C. felis recently. In this study, 66 C. felis isolates from the United States, Jamaica, Peru, Portugal, Slovakia, Nigeria, Ethiopia, Kenya, China, India and Australia were subtyped using the newly established tool. Forty-four specimens yielded gp60 sequences, generating 23 subtypes clustered in 4 subtype families (XIXa, XIXc, XIXd and XIXe) with high bootstrap support in a phylogenetic analysis of sequence data. Among them, XIXa showed high genetic diversity at the nucleotide level, with the formation of 18 subtypes from both cats and humans with different geographic distribution. In contrast, all 11 XIXd isolates derived from humans from various countries had identical sequences. Results of this study improve our understanding of the genetic diversity, host specificity and transmission dynamics of C. felis.
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