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Updated: Dec 4, 2025
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Lanthanide nanoparticles with efficient near-infrared-II emission for biological applications
Xiaoqian Ge1, Ruoyan Wei1, Lining Sun1
1Research Center of Nano Science and Technology, College of Sciences, Shanghai University, Shanghai 200444, China. lnsun@shu.edu.cn.
Abstract:
The near-infrared II (NIR-II) light (1000-1700 nm) possesses deep penetration capability and high signal-to-noise ratios due to the advances of low autofluorescence and scattering in biological tissues. Differing from the traditional NIR-II-emitting nanoprobes such as carbon nanotubes (CNT), organic dyes, quantum dots (QDs), and polymer dots (PDs), lanthanide-doped NPs feature the characteristic of excellent photo-and-chemical stability, sharp emission peaks, longer lifetime, and larger anti-Stokes shift. These merits have impelled the development of NIR-II-emitting lanthanide NPs in biomedical applications at a terrific speed. In this mini-review, we discuss how to design efficient NIR-II-emitting lanthanide NPs and summarize their recent progress in bioimaging, therapy, and biosensing. Moreover, the limitations and future opportunities of NIR-II-emitting lanthanide NPs are also discussed.
