Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ethics in Research

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dietary diversity and nutritional status of children enrolled in Anganwadis of Anekal Taluk, Bengaluru Urban District.

Journal of family medicine and primary care·2026

Same author

Withdrawal of care at end of life: Ethical and legal perspectives.

Indian journal of medical ethics·2026

Same author

Qualitative research: a needed but neglected form of inquiry in nutrition.

European journal of clinical nutrition·2026

Same author

Usability Evaluation and Perceived Performance of the MoonWalking<sup>®</sup> Insole in Safety Footwear.

Sensors (Basel, Switzerland)·2026

Same author

A Comprehensive Profile of Volunteer Firefighters: Sociodemographic and Occupational Dimensions.

Workplace health & safety·2026

Same author

Nutritional status of under-5 children in Bangalore city during the COVID-19 pandemic.

Journal of family medicine and primary care·2025

Search research articles

Related Experiment Video

Updated: Dec 4, 2025

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

Public perceptions on Controlled Human Infection Model (CHIM) studies-a qualitative pilot study from South India.

Manjulika Vaz¹, Olinda Timms², Avita Rose Johnson³

¹Division of Health and Humanities, St John's Research Institute, St John's Medical College, Bangalore, 560034, India. manjulikavaz@sjri.res.in.

Monash Bioethics Review

|October 21, 2020

Summary

Public perception of Controlled Human Infection Models (CHIMs) in India is crucial before introducing such research. Key concerns include safety, ethical considerations, and clear communication of public health benefits, with specific participant profiles identified.

Keywords:

CHIM Challenge studies Human infection studies India Public engagement Public perceptions Research ethics Vaccines

More Related Videos

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Related Experiment Videos

Last Updated: Dec 4, 2025

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Area of Science:

Medical research ethics
Public health policy
Clinical trial methodology

Background:

Controlled Human Infection Models (CHIMs) are a novel research approach not yet implemented in India.
Understanding public and key opinion maker perceptions is vital for the ethical introduction of CHIM studies.
Existing research paradigms in India may not fully align with the unique ethical considerations of CHIMs.

Purpose of the Study:

To explore the perceptions of the general public and key opinion makers regarding the potential introduction of CHIM research in India.
To identify ethical concerns, perceived risks, and potential benefits associated with CHIM studies from a public perspective.
To inform strategies for public engagement and ethical oversight for future CHIM research in the country.

Main Methods:

Qualitative research employing Focus Group Discussions and In-depth Interviews.
Data collected from 110 respondents in urban and rural Bangalore district.
Grounded theory analysis applied to understand emergent themes and perceptions.

Main Results:

Safety concerns, including fear of death and long-term effects, were paramount for the public.
Ethical considerations centered on infecting healthy volunteers and the potential for exploitation of vulnerable populations.
Public good outcomes were seen as justification, but comprehension of benefits and alternatives to CHIMs were noted concerns.
A deflection of suitable participants was observed, with specific demographics identified as potential volunteers (risk-takers, health-literate, altruistic individuals).

Conclusions:

Widespread awareness and advocacy are essential for the ethical implementation of CHIMs in India.
Engaging with diverse public voices and ensuring transparent communication are critical first steps.
Building public trust in research and regulatory systems requires sustained, inclusive deliberative processes.