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Related Experiment Video

Updated: Dec 4, 2025

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Published on: November 19, 2014

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.

Xinzhu Yu¹, Jun Nagai¹, Maria Marti-Solano²

¹Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.

|October 21, 2020

Summary

This summary is machine-generated.

Astrocytes in the brain respond uniquely to different conditions. Targeting specific astrocyte pathways, like G protein-coupled receptor (GPCR) signaling, can improve brain disorder phenotypes in Huntington's disease (HD).

Keywords:

GPCR HD RNA sequencing astrocyte behavior calcium context-specific neuroimmune perturbation striatum synaptogenic

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Last Updated: Dec 4, 2025

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Published on: March 20, 2014

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Astrocytes are crucial glial cells in the central nervous system.
Their role in brain diseases is significant but molecular mechanisms are not fully understood.
Understanding astrocyte responses is key to developing new therapies for neurological disorders.

Purpose of the Study:

To investigate context-specific molecular responses of striatal astrocytes.
To identify astrocyte pathways involved in Huntington's disease (HD).
To explore therapeutic potential of modulating astrocyte signaling in HD.

Main Methods:

Performed astrocyte gene expression analyses across 14 experimental perturbations.
Utilized data mining to identify astrocyte pathways in HD models.
In vivo selective stimulation of astrocyte G protein-coupled receptor (GPCR) pathways.

Main Results:

Striatal astrocytes exhibit context-specific gene, pathway, and regulator responses.
Identified reciprocal alterations in astrocyte pathways and GPCR signaling in HD.
Stimulation of the astrocyte G_i-GPCR pathway ameliorated HD-associated astrocytic, synaptic, and behavioral deficits.

Conclusions:

Astrocytes are adaptable cells with context-specific molecular responses.
Astrocyte signaling pathways, particularly GPCRs, can be molecularly dissected.
Modulating astrocyte pathways offers a potential therapeutic strategy for brain disorders like HD.