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A New Method for Inducing a Depression-Like Behavior in Rats
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Mobility performance predicts incident depression: A systematic review and meta-analysis.
L L Y Chan1, Y Okubo2, M A Brodie3
1School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Experimental Gerontology
|October 21, 2020
Summary
Slow gait speed, a measure of mobility impairment, predicts the future onset of depressive symptoms. This finding highlights the link between physical function and mental health in predicting depression risk.
Area of Science:
- Gerontology
- Epidemiology
- Psychiatry
Background:
- Impaired mobility and depression frequently coexist.
- Evidence is lacking on whether mobility issues precede depression onset.
- Understanding this temporal relationship is crucial for early intervention.
Purpose of the Study:
- To systematically review and meta-analyze cohort studies.
- To determine if mobility impairment predicts incident depression.
- To assess the predictive value of mobility measures for new-onset depression.
Main Methods:
- Systematic search of MEDLINE, EMBASE, CINAHL, and PsycINFO.
- Inclusion of cohort studies with baseline assessment and follow-up for depression.
- Meta-analysis of studies reporting on mobility impairment and incident depressive symptoms.
Main Results:
- 13 cohort studies met eligibility criteria, with 8 of high methodological quality.
- Follow-up periods ranged from 12 months to 16 years.
- Slow gait speed significantly predicted depressive symptoms (pooled OR = 1.93, 95% CI: 1.54 to 2.42).
Conclusions:
- Slow gait speed is a significant predictor of developing depressive symptoms.
- Mobility impairment, specifically reduced gait speed, may precede the onset of depression.
- Findings suggest potential for mobility assessment in depression risk prediction.
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