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Updated: Dec 4, 2025

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Childhood Glaucoma Profile in a Brazilian Tertiary Care Center Using Childhood Glaucoma Research Network

Nara L Lopes1, Carolina P B Gracitelli1,2, Christiane Rolim-de-Moura1

  • 1Department of Ophthalmology and Visual Science, Federal University of São Paulo.

Journal of Glaucoma
|October 21, 2020
PubMed

Insights

The Childhood Glaucoma Research Network (CGRN) classification effectively categorizes pediatric glaucoma subtypes. This standardized approach aids diagnosis and management, improving physician communication and future research in childhood glaucoma.

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Medical Classification Systems

Background:

  • Childhood glaucoma encompasses a group of rare, severe eye conditions.
  • Accurate classification is crucial for effective diagnosis, treatment, and research.
  • The Childhood Glaucoma Research Network (CGRN) developed a new classification system.

Purpose of the Study:

  • To apply the CGRN classification to children diagnosed with glaucoma in a Brazilian tertiary care center.
  • To determine the prevalence and characteristics of each childhood glaucoma subtype.
  • To evaluate the utility of the CGRN classification in a real-world clinical setting.

Main Methods:

  • Retrospective analysis of medical records from a pediatric glaucoma clinic (January 2010 - January 2018).
  • Data collected included initial and reclassified diagnoses (CGRN), age, sex, visual acuity, and affected eye.
  • Patients were categorized according to the 7 CGRN classification groups.

Main Results:

  • 496 patients with confirmed childhood glaucoma or glaucoma suspect were analyzed.
  • Mean age at diagnosis was 3.62 years; 56.65% were male, and 81.16% had bilateral disease.
  • Reclassification using CGRN changed 48.59% of initial diagnoses; primary congenital glaucoma (43.95%) was most common, juvenile open-angle glaucoma (0.40%) least common.

Conclusions:

  • The CGRN classification is a valuable tool for categorizing childhood glaucoma.
  • A standardized classification system improves diagnosis, management, and communication among healthcare professionals.
  • Implementing the CGRN classification can enhance future research endeavors in pediatric glaucoma.
Abstract

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