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Macromolecular turnover in brain during aging
A M Giuffrida Stella1, A Lajtha
1Institute of Biochemistry, Faculty of Medicine, University of Catania, Italy.
Gerontology
|January 1, 1987
Abstract:
During aging there are several structural, functional and biochemical alterations, including changes in macromolecular composition and turnover. Regulation of gene expression, DNA and RNA synthesis, total poly(A)+ and poly(A)- RNA contents, qualitative and quantitative changes of synaptosomal plasma membrane proteins, diminished plasticity, loss of synapses, lower rate of axoplasmic transport, impairment of antioxidant and bioenergetic systems seem to be involved in the aging process of nervous system.