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Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices
Peuli Nath1, Alamgir Kabir1, Somaiyeh Khoubafarin Doust1
1Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606, USA.
Abstract:
Infectious diseases caused by bacteria and viruses are highly contagious and can easily be transmitted via air, water, body fluids, etc. Throughout human civilization, there have been several pandemic outbreaks, such as the Plague, Spanish Flu, Swine-Flu, and, recently, COVID-19, amongst many others. Early diagnosis not only increases the chance of quick recovery but also helps prevent the spread of infections. Conventional diagnostic techniques can provide reliable results but have several drawbacks, including costly devices, lengthy wait time, and requirement of trained professionals to operate the devices, making them inaccessible in low-resource settings. Thus, a significant effort has been directed towards point-of-care (POC) devices that enable rapid diagnosis of bacterial and viral infections. A majority of the POC devices are based on plasmonics and/or microfluidics-based platforms integrated with mobile readers and imaging systems. These techniques have been shown to provide rapid, sensitive detection of pathogens. The advantages of POC devices include low-cost, rapid results, and portability, which enables on-site testing anywhere across the globe. Here we aim to review the recent advances in novel POC technologies in detecting bacteria and viruses that led to a breakthrough in the modern healthcare industry.
Insights
Rapid point-of-care (POC) diagnostic devices offer a low-cost, portable solution for detecting infectious bacteria and viruses. These advanced technologies are revolutionizing healthcare by enabling quick, on-site testing globally.
Area of Science:
- Biomedical Engineering
- Infectious Disease Diagnostics
- Nanotechnology
Background:
- Infectious diseases caused by bacteria and viruses pose significant global health threats, necessitating rapid and accurate diagnostic methods.
- Conventional diagnostic techniques often involve costly equipment, long wait times, and specialized personnel, limiting their accessibility, especially in resource-limited settings.
- The emergence of pandemics like COVID-19 highlights the critical need for accessible and immediate diagnostic solutions.
Purpose of the Study:
- To review recent advancements in novel point-of-care (POC) technologies for the rapid detection of bacterial and viral infections.
- To highlight how these POC devices are transforming modern healthcare diagnostics.
- To discuss the integration of plasmonics and microfluidics in developing sensitive and portable diagnostic platforms.
Main Methods:
- Review of current literature on point-of-care diagnostic technologies.
- Focus on plasmonics and microfluidics-based platforms for pathogen detection.
- Integration of mobile readers and imaging systems for enhanced POC diagnostics.
Main Results:
- POC devices based on plasmonics and microfluidics demonstrate rapid and sensitive pathogen detection capabilities.
- These devices offer advantages such as low cost, portability, and ease of use, enabling on-site testing.
- Recent technological breakthroughs are making POC diagnostics more accessible and effective worldwide.
Conclusions:
- Novel point-of-care technologies are crucial for the timely diagnosis of bacterial and viral infections.
- The development of low-cost, portable, and rapid diagnostic tools is essential for global health security.
- These advancements represent a significant breakthrough in making infectious disease diagnostics more accessible and efficient across diverse healthcare settings.
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