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Bucillamine-induced gigantomastia with galactorrhea and hyperprolactinaemia
Tatsuo Mori1, Naoto Yokogawa1, Ryohei Higuchi2
1Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
Modern Rheumatology Case Reports
|October 22, 2020
Summary
Gigantomastia, excessive breast growth, can be a rare side effect of medications. Bucillamine, a D-penicillamine analogue, has been linked to this condition, highlighting the need for awareness.
Area of Science:
- Endocrinology
- Pharmacology
- Dermatology
Background:
- Gigantomastia is excessive breast growth, occasionally an adverse drug event.
- D-penicillamine is the primary cause of drug-induced gigantomastia.
- Bucillamine, a D-penicillamine analogue, has rarely been associated with gigantomastia.
Observation:
- A case of bucillamine-induced gigantomastia is presented.
- The patient experienced acute bilateral breast enlargement and axillary accessory breast tissue.
- Symptoms appeared 7 months after initiating bucillamine therapy.
Findings:
- This report details a second documented case of bucillamine-induced gigantomastia.
- The presentation included rapid breast growth and development of accessory breast tissue.
Implications:
- Increased awareness of bucillamine-induced gigantomastia is crucial.
- Bucillamine is frequently prescribed in Japan and Korea.
- Clinicians should consider bucillamine as a potential cause of rapid breast enlargement.
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