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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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  1. Home
  3. Faecal Immunochemical Test Is Superior To Symptoms In Predicting Pathology In Patients With Suspected Colorectal Cancer Symptoms Referred On A 2ww Pathway: A Diagnostic Accuracy Study.
  1. Home
  3. Faecal Immunochemical Test Is Superior To Symptoms In Predicting Pathology In Patients With Suspected Colorectal Cancer Symptoms Referred On A 2ww Pathway: A Diagnostic Accuracy Study.

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Faecal immunochemical test is superior to symptoms in predicting pathology in patients with suspected colorectal

Nigel D'Souza1,2,3, Theo Georgiou Delisle1,3, Michelle Chen4

  • 1Colorectal Surgery, Croydon University Hospital, Croydon, UK.

Gut
|October 22, 2020

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
clinical decision makingcolonoscopycolorectal cancerendoscopystool markers

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A faecal immunochemical test (FIT) can effectively rule out colorectal cancer (CRC) when negative. A positive FIT result is superior to symptoms for selecting patients needing urgent CRC investigation.

Area of Science:

  • Gastroenterology
  • Oncology
  • Diagnostic Accuracy

Background:

  • Colorectal cancer (CRC) diagnosis relies on timely investigation of symptomatic patients.
  • Faecal immunochemical test (FIT) is a potential tool for selecting patients with suspected CRC symptoms.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of FIT in selecting patients with suspected CRC for urgent investigation.
  • To determine the optimal FIT cut-off for maximizing sensitivity and specificity.

Main Methods:

  • A multicentre, double-blinded diagnostic accuracy study involving 9822 patients across 50 NHS hospitals.
  • Quantitative FIT was performed on patients referred with suspected CRC symptoms.
  • Sensitivity, specificity, and predictive values of FIT at various cut-offs were assessed.

Main Results:

  • The prevalence of CRC was 3.3%.
  • At a cut-off of 2 µg/g, FIT sensitivity was 97.0% and negative predictive value was 99.8%.
  • Positive FIT results showed improved predictive value for CRC compared to symptoms alone.

Conclusions:

  • FIT is highly effective in ruling out CRC when results are negative at a 2 µg/g cut-off.
  • FIT is a valuable tool for selecting patients with suspected CRC symptoms for urgent investigation.
  • Utilizing FIT can enhance the efficiency of CRC diagnostic pathways.