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[Psoriasis and bullous pemphigoid].

K Bork1

  • 1Hautklinik der Johannes Gutenberg-Universität Mainz.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|June 1, 1987
PubMed
Summary

Psoriasis and bullous pemphigoid can coexist, sometimes linked to psoriasis treatments. A case suggests a potential direct pathogenetic relationship between these two distinct skin conditions.

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Area of Science:

  • Dermatology
  • Autoimmune Blistering Diseases

Background:

  • Psoriasis and bullous pemphigoid are distinct dermatological conditions.
  • Literature reports coexistence in 44 patients, often linked to antipsoriatic therapies like PUVA, anthralin, tar, and salicylic acid.

Observation:

  • A 46-year-old male with a 20-year history of psoriasis developed bullous pemphigoid without prior therapy.
  • Subsequent exacerbation of both conditions after initial clearing suggested a potential pathogenetic link.

Findings:

  • The described case of bullous pemphigoid in a psoriasis patient occurred without preceding antipsoriatic treatment.
  • A later, simultaneous flare of both psoriasis and bullous pemphigoid supports a possible shared pathogenesis.

Implications:

  • This case highlights a potential direct pathogenetic relationship between psoriasis and bullous pemphigoid, beyond treatment-induced occurrences.
  • Further research is warranted to elucidate the underlying mechanisms connecting these two distinct autoimmune skin diseases.

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