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Surrounding vascular geometry associated with basilar tip aneurysm formation.

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Vessel geometry influences intracranial aneurysm formation. Specific angles and diameters of parent and daughter arteries are linked to basilar artery tip aneurysms (BTA), aiding in risk assessment.

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Area of Science:

  • Neuroimaging
  • Vascular Neurology
  • Biomedical Engineering

Background:

  • Hemodynamic stress is a key factor in intracranial aneurysm development.
  • Vessel geometry significantly influences aneurysm formation, particularly at specific locations like the basilar artery tip.

Purpose of the Study:

  • To identify image-based morphological parameters associated with basilar artery tip aneurysms (BTA).
  • To investigate location-specific vascular geometry factors contributing to BTA formation.

Main Methods:

  • Analysis of 3D morphological parameters from CT-angiography (CTA) or digital subtraction angiography (DSA).
  • Evaluation of 207 BTA patients and 106 control patients with aneurysms elsewhere.
  • Statistical analysis including univariable, multivariable, and sensitivity analyses.

Main Results:

  • A wider daughter-daughter angle was directly associated with BTAs.
  • Larger parent artery diameter and diameter size ratio were inversely associated with BTAs.
  • These findings were consistent in subgroup analyses of small aneurysms and when excluding angles.

Conclusions:

  • Easily measurable vascular parameters like vessel angles and diameters can help stratify BTA formation risk.
  • These morphological parameters are robust and unlikely to be altered by aneurysm presence.
  • Identifying these geometric factors aids in predicting BTA risk in susceptible individuals.