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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Related Experiment Video

Updated: Dec 4, 2025

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
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Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion

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Deconstructing tumor heterogeneity: the stromal perspective.

Renee E Vickman1,2, Douglas V Faget3,2, Philip Beachy4

  • 1Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Oncotarget
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

Non-immune stromal cells critically regulate tumor heterogeneity, impacting growth and therapy resistance. Understanding these stromal elements is key to identifying new cancer treatment strategies.

Keywords:
cellular plasticityextracellular matrixstromal heterogeneitytherapy resistancetumor microenvironment

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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

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Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Immune cells' role in tumor progression is known, but non-immune stromal components remain poorly understood.
  • Stromal elements significantly influence tumor heterogeneity, initiation, progression, and therapeutic resistance.

Purpose of the Study:

  • To highlight and integrate the functions of non-immune stromal components in regulating tumor heterogeneity.
  • To explore the dual roles of tumor-supportive versus tumor-suppressive stroma.
  • To identify challenges and knowledge gaps regarding the tumor microenvironment.

Main Methods:

  • NCI-sponsored workshop integrating diverse research perspectives.
  • Discussions on cellular composition, function, and spatial geography of the tumor microenvironment.
  • Exploration of prognostic and therapeutic implications of stromal elements.

Main Results:

  • Non-immune stromal components critically regulate tumor heterogeneity.
  • Stromal composition and function can change during disease progression, influencing tumor behavior.
  • Microenvironment and spatial factors dictate lesion aggressiveness and therapeutic response.

Conclusions:

  • Further research is needed to define the roles of non-immune stromal cells in cancer.
  • Understanding the tumor microenvironment is crucial for developing effective cancer therapies.
  • Identifying vulnerabilities within the heterogeneous tumor microenvironment presents therapeutic opportunities.