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Updated: Dec 4, 2025

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Adiponectin: Role in Physiology and Pathophysiology.

Thi Mong Diep Nguyen1

  • 1Department of Applied Biology and Agriculture, Faculty of Natural Science, Quy Nhon University, 170 An Duong Vuong Street, Quy Nhon City, Binh Dinh Province, Vietnam.

International Journal of Preventive Medicine
|October 22, 2020
PubMed
Summary

Adiponectin regulates glucose and lipid metabolism, improving insulin sensitivity. This review explores its physiological and pathophysiological roles, highlighting its potential in treating type 2 diabetes and obesity-related diseases.

Keywords:
AdipoRAdipokinesadiponectinobesitytype 2 diabetes mellitus

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Area of Science:

  • Endocrinology
  • Metabolic Research

Background:

  • Adiponectin, an adipokine from adipocytes, is vital for metabolic homeostasis.
  • It regulates glucose, lipid metabolism, and insulin sensitivity via AdipoR1/AdipoR2.
  • Elevated adiponectin levels, seen with weight loss, correlate with improved insulin sensitivity.

Purpose of the Study:

  • To review current knowledge on adiponectin.
  • To analyze adiponectin's role in physiology and pathophysiology.
  • To explore its therapeutic potential for metabolic diseases.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of studies on adiponectin's mechanisms.
  • Synthesis of data on adiponectin's involvement in disease.

Main Results:

  • Adiponectin exhibits anti-inflammatory, anti-fibrotic, and antioxidant properties.
  • It enhances insulin sensitivity by improving glucose and lipid metabolism.
  • The adiponectin pathway is implicated in type 2 diabetes and obesity-related conditions.

Conclusions:

  • Adiponectin is a key regulator of metabolic health.
  • Its pathway offers therapeutic targets for insulin resistance, diabetes, and associated diseases.
  • Further research into adiponectin's functions is warranted for drug development.