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Draft genome sequence data and comparative analysis of Erysipelothrix Rhusiopathiae vaccine strain VR-2.
Svetlana N Kovalchuk1, Anna V Babii1
1Federal Science Center for Animal Husbandry Named After Academy Member L.K. Ernst, Dubrovitsy 60, Podolsk Municipal District, 142132 Moscow Region Russian Federation.
The genome of the Erysipelothrix rhusiopathiae VR-2 vaccine strain was sequenced, revealing genetic variability. This information aids in differentiating vaccine strains from field isolates for swine erysipelas monitoring.
Area of Science:
- Veterinary microbiology
- Genomics
- Vaccinology
Background:
- Erysipelothrix rhusiopathiae VR-2 is a live attenuated vaccine used in pigs against swine erysipelas.
- This vaccine is commercially available and widely used in several countries.
Observation:
- The draft genome sequence of E. rhusiopathiae VR-2 is 1,704,727 bp with 1680 genes.
- Comparative analysis showed significant genetic variability in key chromosomal regions.
Findings:
- Twelve genomic loci potentially specific to the E. rhusiopathiae VR-2 strain were identified.
- Genetic variability exists in regions crucial for antigenicity and virulence.
Implications:
- Data can help develop genetic assays to differentiate vaccine strains from field isolates.
- This is vital for epizootical monitoring of swine erysipelas.
- Findings may inform the design of new recombinant vaccines against swine erysipelas.
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