A How-to Guide to Building a Robust SARS-CoV-2 Testing Program at a University-Based Health System

Area of Science:

• Infectious Diseases
• Public Health
• Clinical Diagnostics

Background:

• South Florida experienced a surge in COVID-19 cases in March 2020, necessitating rapid development of diagnostic testing.
• Limited reagent availability presented a significant challenge to establishing widespread SARS-CoV-2 detection.

Purpose of the Study:

• To describe the rapid development and implementation of a comprehensive SARS-CoV-2 testing program.
• To outline strategies for overcoming resource limitations and establishing efficient testing protocols during a public health crisis.

Main Methods:

• Assembled a transdisciplinary team of experts.
• Established multiplatform testing using polymerase chain reaction (PCR) and serology.
• Implemented drive-through facilities and developed testing guidelines.
• Collaborated with research scientists, diagnostic companies, and government officials.
• Created dedicated workforces for sample processing, testing, and contact tracing.
• Integrated testing platforms with the electronic medical record (EMR).

Main Results:

• Achieved capability to test hundreds of healthcare workers and patients daily within three weeks.
• Successfully implemented both Food and Drug Administration (FDA)-authorized and laboratory-developed testing protocols.
• Established efficient SARS-CoV-2 testing and contact tracing for patients and employees.

Conclusions:

• The rapid, collaborative approach enabled the creation of a robust testing program under challenging circumstances.
• The experience provides a valuable model for other institutions facing similar public health emergencies.
• Effective crisis response requires interdisciplinary teamwork, strategic resource management, and technological integration.