Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midtrimester abortion with prostaglandin and hypertonic saline--a comparative study.

R V Bhatt, S Pachauri, E Koshy

    International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
    |January 1, 1978
    PubMed
    Summary

    Comparing intraamniotic prostaglandin F2alpha (PGF2alpha) and 20% saline for pregnancy termination, 20% saline showed higher effectiveness and fewer side effects. Saline resulted in significantly lower rates of incomplete abortion and faster procedures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Erratum to "Comparison of cardiovascular responses after injection of lidocaine with either clonidine or adrenaline: a two-year comparative analysis" [Br J Oral Maxillofac Surg 55 (2017) 67-70].

    The British journal of oral & maxillofacial surgery·2017
    Same author

    Comparison of cardiovascular responses after injection of lidocaine with either clonidine or adrenaline: a two-year comparative analysis.

    The British journal of oral & maxillofacial surgery·2016
    Same author

    Combined trabeculotomy-trabeculectomy with antimetabolite and releasable suture: outcome with primary congenital glaucoma in a north Indian population.

    Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH·2015
    Same author

    Response to Asimakopoulos et al.

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2015
    Same author

    Investigating the Role of Plasma Glucose Concentration as a Phenotypic Marker for CYP2C9 Genetic Variants, in the Diabetic Population of Gujarat.

    Indian journal of pharmaceutical sciences·2014
    Same author

    Sore throat consultations in general practice prior to tonsillectomy among eight hundred and sixty-three children in England: is this in accordance with the SIGN guidelines?

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2013

    Area of Science:

    • Obstetrics and Gynecology
    • Reproductive Medicine
    • Pharmacology

    Background:

    • Second-trimester pregnancy termination is a critical aspect of reproductive healthcare.
    • Evaluating different intraamniotic agents for efficacy and safety is essential for optimizing clinical practice.

    Purpose of the Study:

    • To compare the safety and effectiveness of intraamniotic prostaglandin F2alpha (PGF2alpha) versus 20% saline, both augmented with oxytocin, for second-trimester pregnancy termination.
    • To assess method failure rates, incomplete abortion rates, procedural time, and incidence of side effects.

    Main Methods:

    • A comparative study involving 200 pregnancies between 14 and 20 weeks' gestation.
    • Intraamniotic administration of either PGF2alpha or 20% saline, with intravenous oxytocin augmentation.

    Related Experiment Videos

  • Evaluation of outcomes including method success, abortion completeness, and adverse events.

    • Main Results:

    • 20% saline demonstrated no method failures, while PGF2alpha had ten failures.
    • Incomplete abortion rates were significantly lower with saline (19.4%) compared to PGF2alpha (33.7%).
    • Saline resulted in a significantly shorter mean instillation-to-abortion time and lower incidence of gastrointestinal side effects and bleeding.

    Conclusions:

    • Intraamniotic 20% saline augmented with oxytocin is a safer and more effective method for second-trimester pregnancy termination than PGF2alpha.
    • 20% saline offers advantages in terms of efficacy, reduced complications, and procedural efficiency.