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Motion correction methods for MRS: experts' consensus recommendations.

Ovidiu C Andronesi1, Pallab K Bhattacharyya2, Wolfgang Bogner3

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NMR in Biomedicine
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

Motion correction is crucial for Magnetic Resonance Spectroscopy (MRS) due to its sensitivity to instability. Prospective real-time correction methods significantly improve MRS data quality and metabolite quantification, especially in motion-prone subjects.

Keywords:
MRSMetabolites-neurochemistryNMR probesmotion correctionnavigatoroptical trackingreal timeshim correction

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Area of Science:

  • Magnetic Resonance Spectroscopy (MRS)
  • Medical Imaging
  • Biophysics

Background:

  • MRS is highly sensitive to motion and B0 field instability due to long acquisition times and low signal-to-noise ratio.
  • Motion degrades MRS data quality by altering localization and B0 homogeneity, impacting metabolite quantification.

Purpose of the Study:

  • To review and highlight the importance of motion correction strategies in Magnetic Resonance Spectroscopy (MRS).
  • To discuss the advantages of prospective real-time correction methods for improving MRS data quality and stability.

Main Methods:

  • Subject immobilization, retrospective correction, and prospective real-time correction using internal/external tracking.
  • Prospective methods simultaneously update localization and B0 field using navigators and real-time shim hardware adjustments.
  • Internal and external tracking offer submillimeter/subdegree precision for localization; internal methods update scanner shims.

Main Results:

  • Real-time correction significantly enhances MRS acquisition stability and quantification accuracy.
  • Enables robust measurement of low-concentration metabolites like GABA and glutathione in challenging patient populations.
  • Demonstrated effectiveness in clinical studies involving children and patients with movement disorders.

Conclusions:

  • Motion correction is essential for reliable MRS acquisition and quantification.
  • Prospective real-time correction is a powerful tool for improving MRS data quality, particularly in susceptible subjects.
  • Tighter integration and wider availability of motion correction methods by manufacturers are recommended for MRS users.