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Antifungal agents in dermatology.
1Department of Dermatology, Medical College of Georgia, Augusta 30912-7400.
Journal of the American Academy of Dermatology
|September 1, 1987
Summary
New antifungal medications are increasingly synthetic, moving beyond traditional antibiotics. This review covers existing and emerging treatments, including azoles and allylamines.
Area of Science:
- Pharmacology
- Medicinal Chemistry
- Infectious Diseases
Background:
- Antifungal drug development has surged in the last 20 years.
- Recent trends favor synthetic agents over antibiotics.
- Fungal infections pose a significant global health challenge.
Purpose of the Study:
- To review current and investigational antifungal medications.
- To highlight the shift towards synthetic antifungal agents.
- To provide an overview of different antifungal classes.
Main Methods:
- Literature review of antifungal agents.
- Categorization of antifungals by development stage and chemical class.
- Discussion of over-the-counter, antibiotic, older azole, newer azole, and allylamine agents.
Main Results:
- Significant progress in developing novel antifungal therapies.
- Increasing focus on synthetic compounds.
- Established classes include older azoles, while newer azoles and allylamines represent emerging options.
Conclusions:
- The landscape of antifungal agents is evolving towards synthetic compounds.
- Allylamines represent a new class of antifungals.
- Continued research is crucial for combating fungal infections effectively.