Cryptococcal cellulitis in renal transplant recipients

We report three cases of cryptococcal cellulitis in renal transplant recipients and review five other cases in the literature. Seven cases of cryptococcal cellulitis occurring in other immunocompromised states are also reviewed and compared with the renal transplant group. Cryptococcal cellulitis in renal transplant recipients affects the skin of the extremities and is seen along with erythema, induration, tenderness, and superficial ulcerations of varying extent. Histopathologic examination shows either a variable lymphohistiocytic infiltration of the reticular dermis and subcutaneous fat or an acute panniculitis. Organisms may be difficult to find on routine sections, and special stains are recommended. Culture of tissue aspirate is an excellent method of diagnosis.