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Related Experiment Videos

Cryptococcal cellulitis in renal transplant recipients.

K C Carlson1, M Mehlmauer, S Evans

  • 1Department of Pathology and Laboratory Medicine, Los Angeles County, University of Southern California Medical Center 90033.

Journal of the American Academy of Dermatology
|September 1, 1987
PubMed
Summary
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Cryptococcal cellulitis presents as skin infections on the extremities in renal transplant recipients, often with redness and tenderness. Diagnosis is aided by tissue culture, especially when organisms are hard to find on standard examination.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Dermatology

Background:

  • Cryptococcal cellulitis is a rare fungal infection.
  • Renal transplant recipients are immunocompromised, increasing infection risk.
  • Understanding cryptococcal cellulitis in this population is crucial for timely diagnosis and treatment.

Observation:

  • Three cases of cryptococcal cellulitis in renal transplant recipients were identified.
  • Literature review included five additional cases in renal transplant recipients.
  • Seven cases in other immunocompromised states were reviewed for comparison.

Findings:

  • In renal transplant recipients, cryptococcal cellulitis affects extremities with erythema, induration, tenderness, and ulcerations.
  • Histopathology reveals lymphohistiocytic infiltration or acute panniculitis.

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  • Fungal organisms can be difficult to detect on routine sections; special stains are recommended.

    • Implications:

    • Early recognition of cryptococcal cellulitis in renal transplant recipients is vital.
    • Tissue aspirate culture is a highly effective diagnostic method.
    • This study highlights the clinical presentation and diagnostic approaches for cryptococcal cellulitis in a vulnerable patient group.