Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hooke's Law01:26

Hooke's Law

1.2K
Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
1.2K
Residual Stresses in Bending01:18

Residual Stresses in Bending

431
In the study of elastoplastic members subjected to bending moments, understanding the loading and unloading phases is crucial for assessing material behavior and structural integrity. During the loading phase, as the bending moment increases, the material initially responds elastically, adhering to Hooke's Law, where stress is directly proportional to strain. When the load exceeds the yield strength, plastic deformation occurs, resulting in permanent strain and deformation that remains even...
431
Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

283
The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
283
Plastic Behavior01:21

Plastic Behavior

401
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
401
Elastic Strain Energy for Shearing Stresses01:20

Elastic Strain Energy for Shearing Stresses

391
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
391
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

437
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High titer anti-U in pregnancy with absent hemolysis in a U-positive neonate: a case report and literature review.

American journal of clinical pathology·2026
Same author

Viscoelastic testing: Critical appraisal of new methodologies and current literature.

International journal of laboratory hematology·2023
Same author

Sensitivity and specificity of thromboelastography for hyperfibrinolysis: Comparison of TEG 5000 and TEG 6S CK LY30 systems.

American journal of clinical pathology·2023
Same author

Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?

Blood advances·2023
Same author

Decreasing blood wastage during ex vivo lung perfusion recovery through utilization of thermal control technology.

Journal of cardiac surgery·2022
Same author

Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies.

Blood·2022
Same journal

Spray dried plasma manufactured from apheresis and whole blood derived plasma.

Transfusion·2026
Same journal

Identification of a novel ABO*A1.01 allele with c.562C>T (p.Arg188Cys) mutation associated with A<sub>el</sub> phenotype in a Chinese individual.

Transfusion·2026
Same journal

AABB survey on directed blood donation practices.

Transfusion·2026
Same journal

Cost analysis considerations for red blood cell matching to mitigate alloimmunization in patients with sickle cell disease.

Transfusion·2026
Same journal

A novel translation initiation codon single nucleotide variant of the SLC14A1 (c.2T>G) from a Chinese blood donor with Jk(a-b-) phenotype.

Transfusion·2026
Same journal

Size (and frequency) matter: Evaluating the best management practices for blood products with spotty demand.

Transfusion·2026
See all related articles

Related Experiment Video

Updated: Dec 4, 2025

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
07:07

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

32.5K

Basic principles of viscoelastic testing.

Timothy Carll1, Geoffrey D Wool1

  • 1Department of Pathology, University of Chicago, Chicago, Illinois, USA.

Transfusion
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

Viscoelastic testing offers a comprehensive view of blood clotting, assessing both cellular and plasma contributions. This hemostatic analysis method aids in guiding transfusions and detecting clotting abnormalities.

Keywords:
hemostasistransfusion practices (adult)

More Related Videos

Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography
07:57

Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography

Published on: May 10, 2022

2.4K
Studying Large Amplitude Oscillatory Shear Response of Soft Materials
06:07

Studying Large Amplitude Oscillatory Shear Response of Soft Materials

Published on: April 25, 2019

13.3K

Related Experiment Videos

Last Updated: Dec 4, 2025

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
07:07

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

32.5K
Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography
07:57

Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography

Published on: May 10, 2022

2.4K
Studying Large Amplitude Oscillatory Shear Response of Soft Materials
06:07

Studying Large Amplitude Oscillatory Shear Response of Soft Materials

Published on: April 25, 2019

13.3K

Area of Science:

  • Hemostasis and Thrombosis
  • Biomedical Engineering
  • Clinical Pathology

Background:

  • Viscoelastic testing provides a real-time, holistic analysis of ex vivo blood clotting.
  • It examines cellular and plasma protein contributions, including platelet and fibrinogen function.
  • The method assesses physical clot properties during liquid-to-gel transition.

Purpose of the Study:

  • To review the basic principles of viscoelastic testing.
  • To discuss the science and technology behind the method.
  • To cover currently available testing platforms and reagents.

Main Methods:

  • Measurement of clot shear modulus via physical force transduction.
  • Measurement of clot resonance frequency using sonometric interrogation.
  • Analysis of live trace parameters reflecting different hemostatic contributors.

Main Results:

  • FDA-approved viscoelastic instruments are available, with sonometric options offering portability.
  • Reagent kits allow specific interrogation of hemostatic pathways.
  • Testing predicts traditional coagulation assays and detects hypercoagulability/hyperfibrinolysis, reducing transfusions.

Conclusions:

  • Viscoelastic testing is increasingly implemented in clinical settings.
  • The method has demonstrated efficacy in reducing blood transfusion rates.
  • Impact on overall mortality and morbidity requires further demonstration.