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Related Concept Videos

Vaccinations01:51

Vaccinations

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Common Respiratory Disorders01:31

Common Respiratory Disorders

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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
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Overview of Respiratory System01:23

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The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
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Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Drugs Used in Upper Respiratory Disorders: Overview01:16

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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Pneumonia V: Nursing management and Prevention01:30

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Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
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An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
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An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

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Respiratory syncytial virus immunisation overview.

David A Foley1, Linny K Phuong2,3, Janet A Englund4

  • 1Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia.

Journal of Paediatrics and Child Health
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

Respiratory syncytial virus (RSV) causes significant illness in all ages. New vaccines and antibody treatments targeting the RSV F-protein are nearing availability, offering hope for prevention.

Keywords:
immunisationpaediatricrespiratory syncytial virusrespiratory virusvaccine development

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Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Respiratory syncytial virus (RSV) is a major cause of illness and death in children and adults.
  • Natural RSV infection provides limited immunity, leading to repeated infections.
  • Current treatments for RSV are primarily supportive, with no definitive cure.

Purpose of the Study:

  • To review current strategies for preventing RSV infection.
  • To highlight advancements in vaccine and antibody development.
  • To discuss the potential impact of successful RSV prevention.

Main Methods:

  • Review of existing literature on RSV pathogenesis, immunity, and prevention.
  • Analysis of ongoing clinical trials for RSV vaccines and monoclonal antibodies.
  • Evaluation of the RSV F-protein as a target for immunisation.

Main Results:

  • Past vaccine development efforts faced challenges, including enhanced disease.
  • Active (vaccines) and passive (antibodies) immunisation strategies are promising.
  • Maternal vaccines and improved monoclonal antibodies (e.g., Palivizumab) show potential.

Conclusions:

  • Significant progress is being made towards effective RSV prevention.
  • Novel vaccine candidates and antibody formulations are under development.
  • Successful RSV prevention could substantially reduce childhood illness, death, and healthcare costs.