Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurofilament Light Chain as a Biomarker in Neurology.

European neurology·2026
Same author

Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.

Biomedical microdevices·2026
Same author

Comparison FT-IR spectral fingerprints of kidney Cancer in urine and serum: Clinical correlations and diagnostic potential.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Myasthenia gravis and myocarditis induced by immune checkpoint inhibitors: a case report.

Neurologia i neurochirurgia polska·2026
Same author

Monitoring the effect of surgical treatment of carotid atherosclerosis using Raman spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Impact of chronic SSRI administration on memory parameters, lipid components and membrane properties in C57Bl/6J mice.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: Dec 4, 2025

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.3K

Rod-shaped gold nanoparticles exert potent candidacidal activity and decrease the adhesion of fungal cells.

Ewelina Piktel1, Łukasz Suprewicz1, Joanna Depciuch2

  • 1Department of Medical Microbiology & Nanobiomedical Engineering, Medical University of Białystok, PL-15222 Białystok, Poland.

Nanomedicine (London, England)
|October 22, 2020
PubMed
Summary

Rod-shaped gold nanoparticles (AuR NPs) show potent fungicidal activity against various Candida and filamentous fungi strains. These nanoparticles offer a promising new avenue for developing effective antifungal therapies.

Keywords:
Candidafilamentous fungifungal infectionsfungicidal activitygold nanorodsnonspherical nanoparticles

More Related Videos

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.7K
A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

3.4K

Related Experiment Videos

Last Updated: Dec 4, 2025

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.3K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.7K
A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

3.4K

Area of Science:

  • Nanotechnology
  • Mycology
  • Antimicrobial Agents

Background:

  • Fungal infections pose a significant threat, particularly in immunocompromised patients.
  • Drug-resistant fungal strains necessitate novel therapeutic strategies.
  • Gold nanoparticles (AuNPs) are being explored for their antimicrobial potential.

Purpose of the Study:

  • To evaluate the fungicidal efficacy of rod-shaped gold nanoparticles (AuR NPs).
  • To assess AuR NPs against Candida strains from hematooncological patients and filamentous fungi.
  • To elucidate the mechanism of AuR NP-induced fungal cell death.

Main Methods:

  • Colony-counting assays were used to quantify fungal viability.
  • Colorimetric and fluorometric methods assessed nanoparticle interactions.
  • Atomic force microscopy provided insights into morphological changes.

Main Results:

  • AuR NPs demonstrated potent fungicidal activity against all tested fungal isolates.
  • Activity was observed irrespective of fungal species or drug susceptibility.
  • Effective concentrations of AuR NPs were non-toxic to host cells.
  • AuR NPs exhibited membrane-permeabilizing properties and induced reactive oxygen species.

Conclusions:

  • Rod-shaped gold nanoparticles are effective against a broad spectrum of fungi.
  • AuR NPs function by disrupting fungal cell membranes and generating reactive oxygen species.
  • Nonspherical gold nanoparticles show promise as novel antifungals or drug-delivery systems.