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Predigested formula for infants with cystic fibrosis.

P M Farrell¹, E H Mischler, S A Sondel

¹Department of Pediatrics, University of Wisconsin, Madison.

Journal of the American Dietetic Association

|October 1, 1987

Summary

Early introduction of Pregestimil formula significantly improves growth in infants with cystic fibrosis. This predigested formula helps normalize weight by one year, outperforming standard formulas for better growth velocity.

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Area of Science:

Pediatrics
Nutritional Science
Gastroenterology

Background:

Cystic fibrosis (CF) often leads to malnutrition and impaired growth in infants.
Early nutritional intervention is crucial for managing CF and improving long-term outcomes.

Purpose of the Study:

To evaluate the impact of predigested formula (Pregestimil) on growth rates in infants with cystic fibrosis.
To test the hypothesis that Pregestimil can normalize infant weight by 12 months of age when introduced before 6 months.

Main Methods:

A comparative study involving 19 newly diagnosed cystic fibrosis infants.
One group received Pregestimil, while the control group received standard infant formula.
Growth parameters (length, weight, weight percentile, growth velocity) were monitored up to 12 months of age.

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Main Results:

The Pregestimil group demonstrated significantly greater length and weight at 12 months.
Average weight percentile was twofold higher in the Pregestimil group.
Growth velocity was significantly better (556 vs. 423 gm/month) for infants on Pregestimil (p < .001).
All infants on Pregestimil achieved normal weight percentiles (>5th), compared to only 10 out of 19 in the standard formula group (p = .0006).

Conclusions:

Early introduction of Pregestimil formula is effective in normalizing growth in infants with cystic fibrosis.
Predigested formula significantly enhances growth velocity and weight attainment in this population.
Pregestimil represents a valuable nutritional strategy for improving growth outcomes in infants diagnosed with cystic fibrosis.