Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pepsinogen. Prolate ellipsoid or unrecognized pathogen?

M D Basson1, I M Modlin

  • 1Department of Surgery, Yale University School of Medicine, West Haven, Connecticut.

Journal of Clinical Gastroenterology
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multigenomic liquid biopsy biomarker for neuroendocrine tumor disease outperforms CgA and has surgical and clinical utility.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Identification of potential small-molecule protein-protein inhibitors of cancer metastasis by 3D epitope-based computational screening.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2018
Same author

Hierarchies of healing in gut mucosal injury.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2018
Same author

The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2017
Same author

Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors.

European journal of nuclear medicine and molecular imaging·2015
Same author

Akt1 binds focal adhesion kinase via the Akt1 kinase domain independently of the pleckstrin homology domain.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2015

Pepsin, a digestive enzyme, and its precursor pepsinogen are linked to peptic ulcers and gastric cancer. Understanding pepsinogen abnormalities may improve upper gastrointestinal disease treatment.

Area of Science:

  • Gastroenterology
  • Enzymology

Background:

  • Pepsin is a key proteolytic enzyme derived from pepsinogen, secreted by chief cells.
  • Pepsinogen secretion is regulated by cyclic AMP (cAMP) and calcium.
  • Altered pepsinogen levels are associated with peptic ulcer disease and gastric cancer.

Purpose of the Study:

  • To explore the role of pepsin and its isozymogens in gastrointestinal diseases.
  • To clarify the significance of specific pepsinogen abnormalities in gastric cancer.

Main Methods:

  • The abstract does not specify methods.
  • The study likely involves analysis of pepsinogen levels and isozymogens in patient populations.

Main Results:

  • Pepsin contributes to ulcer formation by damaging mucosal barriers.

Related Experiment Videos

  • Certain pepsin isozymogens appear overactive in peptic ulcer disease patients.
  • The role of low pepsinogen with elevated pepsinogen II and pepsin 5 in gastric cancer is unclear.

    • Conclusions:

    • Pepsin's role in ulcerogenesis is significant.
    • Further research into pepsin's pathophysiology is crucial for advancing understanding and treatment of upper gastrointestinal disorders.