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Telomerase expression in clinically non-functioning pituitary adenomas.

Liana Lumi Ogino1, Elisa Baranski Lamback2, Alexandro Guterres1

  • 1Neuropathology and Molecular Genetics Laboratory - Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil.

Endocrine
|October 22, 2020
PubMed
Summary

Human telomerase reverse transcriptase (hTERT) expression was investigated in non-functioning pituitary adenomas (NFPA). The study found hTERT is present in a small fraction of NFPA and does not correlate with tumor aggressiveness or proliferation.

Keywords:
Non-functioning pituitary adenomasPituitary tumorTelomeraseTumorigenesis

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Non-functioning pituitary adenomas (NFPA) are typically benign but can exhibit aggressive behavior.
  • Identifying markers for NFPA aggressiveness and proliferation is crucial for patient management.

Purpose of the Study:

  • To determine the presence of human telomerase reverse transcriptase (hTERT) in NFPA.
  • To evaluate if hTERT expression can serve as a marker for NFPA aggressiveness and proliferation.

Main Methods:

  • Analysis of 109 NFPA samples from 86 patients.
  • Assessment of tumor aggressiveness via radiological progression and proliferation using Ki-67.
  • Quantification of hTERT mRNA levels using quantitative real-time polymerase chain reaction (RT-qPCR).

Main Results:

  • hTERT mRNA was expressed in 6.4% of NFPA samples.
  • Tumor aggressiveness was observed in 66% of cases and proliferation in 47.7%.
  • No significant correlation was found between hTERT expression and tumor aggressiveness or proliferation.

Conclusions:

  • hTERT expression is infrequent in NFPA.
  • hTERT does not appear to be a reliable biomarker for predicting aggressiveness or proliferation in NFPA.