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Related Concept Videos

The Proteasome02:18

The Proteasome

9.7K
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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The Proteasome01:13

The Proteasome

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Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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Caspases01:24

Caspases

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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Updated: Dec 4, 2025

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

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Targeting Proteases for Treating COVID-19.

Binquan Luan1, Tien Huynh1, Xuemei Cheng2

  • 1Computational Biological Center, IBM Thomas J. Watson Research, Yorktown Heights, New York 10598, United States.

Journal of Proteome Research
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

Protease inhibitors show promise for treating coronavirus disease 2019 (COVID-19). Targeting viral and host proteases is crucial for combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its pathogenesis.

Keywords:
ACE2COVID-19SARS-CoV-2TMPRSS2main protease

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Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Coronavirus disease 2019 (COVID-19) poses a significant global health challenge.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relies on proteases for its lifecycle and pathogenesis.
  • Protease inhibitors have demonstrated efficacy against other viral infections.

Purpose of the Study:

  • To review the role of host and viral proteases in COVID-19 pathogenesis.
  • To explore the potential of protease inhibitors as antiviral treatments for COVID-19.
  • To summarize ongoing clinical trials of protease inhibitors for COVID-19.

Main Methods:

  • Literature review of scientific articles and clinical trial data.
  • Analysis of the mechanisms by which proteases contribute to SARS-CoV-2 infection.
  • Synthesis of information on the development and evaluation of protease inhibitors.

Main Results:

  • Host and viral proteases are essential for SARS-CoV-2 entry, replication, and spread.
  • Protease inhibitors offer a targeted therapeutic strategy against SARS-CoV-2.
  • Several protease inhibitors are currently under investigation in clinical trials for COVID-19 treatment.

Conclusions:

  • Protease inhibitors represent a promising therapeutic avenue for managing COVID-19.
  • Targeting proteases could mitigate disease severity and viral transmission.
  • Further research and clinical evaluation are essential to establish the role of protease inhibitors in COVID-19 treatment.