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Related Concept Videos

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Dec 4, 2025

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

Published on: March 22, 2018

Olfactory recognition memory in mice depends on task parameters.

Alison Buseck¹, Katherine McPherson¹, Christiane Linster¹

¹Computational Physiology Lab.

Behavioral Neuroscience

|October 22, 2020

Summary

This summary is machine-generated.

Mice memory for odors lasts up to 15 minutes for one odor and 5 minutes for two odors. Odor memory specificity decreases with longer delays.

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Last Updated: Dec 4, 2025

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

Published on: March 22, 2018

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

Area of Science:

Neuroscience
Animal Behavior

Background:

Assessing olfactory memory in rodents is crucial for understanding memory mechanisms.
Existing methods often require extensive training or animal deprivation, limiting efficiency.

Purpose of the Study:

To develop and validate a simple, rapid odor recognition paradigm for assessing mouse memory.
To determine the duration, span, and specificity of olfactory memory in adult mice.

Main Methods:

A two-trial odor recognition task was employed, requiring no prior training or food/water restriction.
Mice were exposed to one or more odors, followed by a delay, and then tested for recognition.

Main Results:

Mice remembered a single odor for 10-15 minutes and two odors for up to 5 minutes.
Memory for three odors was not observed at tested delays.
Odor recognition specificity declined as the delay interval increased.

Conclusions:

The developed paradigm offers a time-efficient method for evaluating olfactory memory in mice.
Results establish baseline memory parameters for single and multiple odor recognition.
Findings are critical for designing future experiments investigating memory modulation.